Objective:To investigate the safety and efficacy of transcatheter aortic valve replacement(TAVR)in patients with severe aortic stenosis(AS).Methods:The baseline characteristics,imaging evaluation,periopera-tive and postoperative follow-up results of 89 patients with severe AS who underwent TAVR in Zhongshan Peo-ple's Hospital from December 2017 to December 2023 were retrospectively collected,and summarized.Results:The mean age was 74.0(69.5,80.0)years,and the American Society for Thoracic Surgery(STS)score was 4.45％(3.19％,6.49％).Bicuspid aortic valve disease was found in 46 cases(51.69％).All patients received general anesthesia and femoral artery was used as the vascular approach.The 82 patients(92.13％)had self-dila-tation valve and 7 patients(7.87％)had spherical dilatation valve.The technical success rate was 97.75％,and the instrument success rate was 94.38％.The proportion of patients with New York Heart Association(NYHA)grade Ⅲ and Ⅳ decreased after surgery(68.54％vs3.37％,P＜0.001),the N-terminal brain natriuretic peptide prebody decreased significantly,the left ventricular end-diastolic diameter improved,the peak trans-valve pressure decreased,and the peak trans-valve flow rate decreased.Perivalvular leakage was the most common complication in 48 cases(53.93％),and the proportion of mild,moderate and severe perivalvular leakage were 34.83％,15.73％and 3.37％,respectively.There were 13 cases(14.44％)of new atrioventricular block,19 cases(21.35％)of new complete left bundle branch block,and 8 cases(8.99％)of patients needed permanent pacemak-er implantation.Pericardial tamponade occurred in 6 cases(6.74％).There were 3 cases(3.37％)of major vascu-lar complications of surgical approach.Contrast media-induced acute kidney injury was in 9 cases(10.11％);A-cute ischemic stroke occurred in 1 case(1.12％).The mean follow-up time was(23.55±18.08)months,and 10 cases(11.24％)died of all causes.The quality of life of other patients was significantly improved.Conclusion:TAVR is safe and effective in improving the survival rate and quality of life in patients with severe aortic stenosis.
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