原发性心脏滑膜肉瘤1例临床病理分析
Primary synovial sarcoma of the heart:one case report and literature review
袁丹 1张苏园 1纪青 1梁娜 2王进京1
作者信息
- 1. 遵义医科大学附属医院病理科(贵州遵义,563000)
- 2. 遵义医科大学基础医学院组胚教研室
- 折叠
摘要
滑膜肉瘤是一类具有间叶和上皮双向分化的恶性肿瘤,可发生于任何部位,好发于四肢深部软组织,而原发心脏的滑膜肉瘤非常罕见.临床主要表现为心腔阻塞、栓塞和填塞而引起的相应症状.当发生部位不典型时,诊断往往具有挑战性,确诊依靠组织病理学形态、免疫组织化学及分子遗传学检查(SYT-SSX融合基因改变).我们对1例原发心脏滑膜肉瘤的临床资料、病理特征、治疗及随访进行分析,并复习相关文献,以提高临床医师及病理医师对该病的认识.
Abstract
Synovial sarcoma is a type of malignant tumor with bidirectional differentiation of mesenchymal and epithelial cells,which can occur in any location.It mainly affects the deep soft tissues of the limbs,while pri-mary synovial sarcoma of the heart is very rare.The main clinical manifestations are corresponding symptoms caused by cardiac obstruction,embolism,and tamponade.When the site of occurrence is atypical,diagnosis is of-ten challenging,relying on histopathological morphology,immunohistochemistry,and molecular genetic examina-tion(SYT-SSX fusion gene changes)for diagnosis.We analyzed the clinical data,pathological features,treat-ment,and follow-up of a case of primary cardiac synovial sarcoma,and reviewed relevant literature to enhance the understanding of the disease among clinical and pathological physicians.
关键词
心脏滑膜肉瘤/临床病理特征/SS18(SYT)-SSX融合基因/治疗/预后Key words
cardiac synovial sarcoma/clinical pathological characteristics/SS18(SYT)-SSX fusion gene/treatment/prognosis引用本文复制引用
基金项目
遵义市科技计划项目(遵市科合HZ字2023234号)
2024年度贵州省卫生健康委科学技术基金项目(D596号)
遵义医科大学附属医院优秀青年人才培养计划(YC220240423)
出版年
2024
NETL
NSTL
万方数据