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卡度尼利单抗致免疫性心肌炎1例

One case of immune-mediated myocarditis induced by Cadonilimab monoclonal antibody

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免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)已用于治疗多种恶性肿瘤,使肿瘤患者受益.卡度尼利单抗是2022年6月获批的首个PD-1/CTLA-4肿瘤双ICIs,迄今为止尚无使用卡度尼利单抗所致的ICIs相关性心肌炎的报道.本文介绍了 1例使用卡度尼利单抗3个周期后诊断为重症ICIs相关性心肌炎,行糖皮质激素治疗后病情显著改善的病例.此病例强调了卡度尼利单抗诱导ICIs相关性心肌炎的潜在风险,为此类新型免疫抑制剂导致心肌炎的诊断和治疗提供思路.
Immune checkpoint inhibitors(ICIs)have been used to treat various malignant tumors,and benefit cancer patients.Cadonilimab is the first PD-1/CTLA-4 tumor dual ICIs approved in June 2022,and there have been no reports of ICIs associated myocarditis caused by Cadonilimab.This article introduces one case of severe ICIs related myocarditis diagnosed after 3 cycles of using Cadonilimab,and his condition was improved significant-ly after glucocorticoids treatment.This case highlights the potential risk of ICIs related myocarditis induced by Cadonilimab,providing insights for the diagnosis and treatment of ICIs related myocarditis.

Cadonilimabimmune checkpoint inhibitorsimmune myocarditis

丁娣、孙旭森、钱晓琳、王韦、张政

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复旦大学附属中山医院青浦分院心血管内科(上海,201700)

卡度尼利单抗 免疫检查点抑制剂 免疫性心肌炎

2024

10.13201/j.issn.1001-1439.2024.12.015

临床心血管病杂志
华中科技大学心血管病研究所 华中科技大学协和医院

临床心血管病杂志

CSTPCD
影响因子：0.653
ISSN：1001-1439
年,卷(期)：2024.40(12)