皮质激素耐药或依赖的成人免疫性血小板减少症的治疗
Treatments for corticosteroid-resistant or dependent immune thrombocytopenia
彭军1
作者信息
- 1. 山东大学齐鲁医院血液科(济南,250012)
- 折叠
摘要
免疫性血小板减少症(immune thrombocytopenia,ITP)是一种常见的自身免疫性出血性疾病,表现为外周血血小板计数减低.针对ITP的经典初始治疗方案仍为糖皮质激素,但部分患者对糖皮质激素耐药或依赖,随着多种新药的出现及药物联合方案的应用,ITP患者的临床管理已由经典的免疫抑制治疗为主逐渐向个体化方案制定转变.但目前针对激素耐药或依赖的ITP患者的治疗方法尚无明确优先级别推荐.本文将对激素耐药或依赖的ITP患者的治疗进行整理概述,以期为临床医生治疗提供参考.
Abstract
Immune thrombocytopenia(ITP)is a common autoimmune bleeding disorder characterized by de-creased peripheral blood platelet count.The classical initial treatment is corticosteroids for newly diagnosed ITP in adults.However,some patients developed resistance to corticosteroids or become dependent on them.New thera-peutic approaches and the strategic combination have altered the classical immunosuppressive therapies to individu-alized treatments.Until now,the priority of treatments for corticosteroid-resistant or dependent ITP patients is seldom articulated.Here we provide a comprehensive overview of the therapeutic strategies for corticosteroid-re-sistant or dependent ITP patients.
关键词
糖皮质激素耐药/糖皮质激素依赖/免疫性血小板减少症/治疗Key words
corticosteroid-resistant/corticosteroid-dependent/immune thrombocytopenia/treatment引用本文复制引用
出版年
2024
NETL
NSTL
万方数据