New exploration in clinical treatment:All-trans retinoic acid plus low-dose rituximab in the treatment of adult immune thrombocytopenia
Immune thrombocytopenia is an isolated thrombocytopenia characterized by the increased platelet destruction and decreased platelet production mediated by the loss of immune tolerance.Its treatment includes cor-ticosteroids,intravenous immunoglobulin,rituximab,thrombopoietin receptor agonists,immunosuppressants,and splenectomy.Although current therapies are effective for over two-thirds of patients,there are still some pa-tients who cannot achieve long-term efficacy.This article introduces the efficacy,safety,and application prospects of all-trans retinoic acid combined with low-dose CD20 monoclonal antibody in the treatment of adult immune thrombocytopenia.
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