Efficacy and safety of venetoclax and hypomethylating agents in myeloid sarcoma
Objective:To evaluate the efficacy and safety of venetoclax and hypomethylating agents in the treatment of myeloid sarcoma.Methods:The clinical data of 5 patients with myeloid sarcoma treated with veneto-clax and hypomethylating agents were retrospectively analyzed,among them one patient was isolated myeloid sar-coma after allogeneic hematopoietic cell transplantation,the others were accompanied by bone marrow involve-ment.Results:All the patients got lesions disappeared,4 cases with bone marrow invasion achieved complete re-mission,and the main adverse events were bone marrow suppression.By the end of follow-up,four patients were alive and one patient died of subsequent recurrence.Conclusion:The combination of venetoclax and hypomethylat-ing agents can achieve good clinical efficacy in the treatment of myeloid sarcoma,without significant adverse e-vents.
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