The combined application of long-and short-acting granulocyte colony-stimulating factor improved the excellent rate of autologous peripheral blood hematopoietic stem cell collection
Objective:To compare the differences in mobilization,collection,and post-transplant hematopoiet-ic reconstitution of autologous peripheral blood hematopoietic stem cells among the long-and short-acting granulo-cyte colony-stimulating factor(G-CSF)combined regimen(pegylated recombinant human granulocyte colony-stim-ulating factor[PEG-rhG-CSF]+G-CSF),chemotherapy combined with short-acting G-CSF and short-acting G-CSF alone,and figure out which one is more effective.Methods:The clinical data of 71 patients underwent periph-eral blood hematopoietic stem cell transplantation from February 2019 to February 2022 were collected.The re-sults of number of collected cells,success rate and time to hematopoietic reconstruction after transplantation were compared,including long-and short-term G-CSF combined regimen(PEG-rhG-CSF+G-CSF group,n=12),chemotherapy combined with short-term G-CSF(chemotherapy+G-CSF group,n=34),and short-term G-CSF alone(G-CSF group,n=25),and the factors affecting the efficacy of mobilization were analyzed.Results:There were significant differences in the number of CD34+cells,excellent rate of collection,and hematopoietic recon-struction time among the three groups(P＜0.05).The number of CD34+cells collected([15.77±5.44]×106/kg vs[4.30±0.59]X 106/kg,P=0.001)and the excellent rate(100.0％vs 32.0％,P=0.001)in the PEG-rhG-CSF+G-CSF group were significantly better than those in the G-CSF group,and the number of CD34+cells col-lected([15.77±5.44]× 106/kg vs[8.34±0.94]×106/kg,P=0.034)and the excellent rate(100.0％vs 73.5％,P=0.049)in the PEG-rhG-CSF+G-CSF group were better than those in the chemotherapy+G-CSF group.In terms of hematopoietic reconstruction,the granulocyte recovery time([10.25±0.78]d vs[12.56± 0.69]d,P=0.042)and the platelet recovery time([10.42±0.41]d vs[12.68±0.70]d,P=0.035)in the PEG-rhG-CSF+G-CSF group were better than those in the G-CSF group,and the granulocyte recovery time([10.25± 0.78]d vs[13.68±0.42]d,P=0.001)and platelet recovery time([10.42±0.41]d vs[13.15±0.41]d,P=0.007)in the PEG-rhG-CSF+G-CSF group were better than those in the chemotherapy+G-CSF group.There was no significant difference in acquisition success rate among the three groups(P＞0.05).All patients success-fully achieved hematopoietic reconstruction after transplantation,and no transplant-related death occurred.Conclusion:Compared with chemotherapy+G-CSF and G-CSF mobilization alone,the long-and short-acting G-CSF combined mobilization regimen has higher CD34+cell collection number and good rate of collection,and sig-nificantly shortens the time of hematopoietic reconstruction.This mobilization regimen can be a good option for autologous peripheral blood mobilization in patients with malignant hematological diseases.
NETL
NSTL
万方数据
