Progress of novel therapy in the treatment of chronic lymphocytic leukemia transforming Richter syndrome
Richter syndrome refers to an aggressive lymphoma that develops based on chronic lymphocytic leukemia/small lymphocytic lymphoma(CLL/SLL).The majority of transformed patients currently have an infe-rior prognosis,and in particular,conventional chemoimmunotherapy showed poor efficacy in clonal related pa-tients:This group of patients may benefit from combinations of novel targeted agents and/or cellular immunother-apy.These new strategies also offer opportunities for patients who are age-appropriate for transplantation.In this review,we focus on current advances related to the therapeutic strategies available for this disease.
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