Clinical study on coagulation function and immune function in patients undergoing ECMO treatment after blood transfusion
Objective:To investigate the effects of blood transfusion therapy on coagulation and immune func-tion in patients undergoing extracorporeal membrane oxygenation(ECMO)therapy.Methods:56 patients who underwent ECMO treatment and blood transfusion treatment in our hospital from February 2020 to February 2022 were selected The changes of electrolyte,coagulation function,humoral immunity and cellular immunity in patients before and after blood transfusion were compared statistically.Results:After blood transfusion treat-ment,the levels of K+and Na+in ECMO patients decreased compared to before transfusion,and there was a sta-tistically significant difference in K+levels after transfusion(P＜0.05),while there was no significant change in blood Ca2+levels,The activated partial thromboplastin time,prothrombin time and thrombin time increased,while the platelet count and fibrinogen concentration decreased,and the difference was statistically significant(P＜0.05).After blood transfusion,the serum immunoglobulin IgA,IgG,IgM levels,NK cell count,CD4+content,and CD4+/CD8+ratio of patients decreased,while the CD8+content increased,with statistical significance(P＜0.05).Conclusion:After blood transfusion,ECMO patients may experience abnormalities in electrolytes,coagu-lation function,and immune function indicators.In clinical practice,high attention should be paid to the manage-ment of blood transfusion in ECMO patients,reducing the transfusion of allogeneic blood and adverse reactions,improving the efficacy of blood transfusion,and ensuring patient safety.
extracorporeal membrane oxygenationblood transfusioncoagulation functionimmunologic function
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