Application of thromboelastography in patients with inflammatory bowel disease or colorectal polyps
Objective:To investigate the changes of coagulation function in patients with inflammatory bowel disease(IBD)or colorectal polyps,and evaluate the value of thromboelastography(TEG)in monitoring coagulation function.Methods:The parameters of TEG,including reaction time(R),clot kinetics(K),clot strengthening(Angle),maximum amplitude(MA),were retrospectively analyzed in 50 patients with IBD and 85 patients with colorectal polyps treated in hospital from January 2021 to December 2022,and these parameters of 139 healthy subjects were used as the control group.In addition,the correlation between TEG parameters and conventional coagulation indexes,such as thrombin time(TT),activated partial thromboplastin time(APTT),prothrombin time(PT),D-Dimer and fibrinogen(Fib)was analyzed.Results:Compared with the control group,the R and K of IBD patients were significantly decreased,MA was significantly increased(P＜0.05).In colorectal polyp patients,R,K and Angle were smaller than those in control group,and the MA was higher than that of the control group,with statistical significance(P＜0.05).Spearman correlation analysis showed that R was positively correlated with APTT and TT in IBD patients,K was positively correlated with TT,and negatively correlated with Fib and D-Di-mer.Angle was negatively correlated with TT and D-Dimer,but positively correlated with Fib.MA was also pos-itively correlated with Fib and D-Dimer(P＜0.05).In colorectal polyp patients,there was a significant positive correlation between R and APTT,K was positively correlated with APTT and TT,and there was significant posi-tive correlation between MA and Fib,all had linear relationship(P＜0.05).Conclusion:TEG may play an impor-tant role in monitoring coagulation status in the patients with IBD or colorectal polyps.TEG and conventional co-agulation tests can complement each other but not replace each other in the assessment of coagulation function in the two diseases.
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