Analysis of liver injury in neonates with different degrees of hyperbilirubinemia
Objective:To analyze the degree of liver injury in neonates with different degrees of hyperbilirubi-nemia using related liver function indexes.Methods:The clinical data of 191 neonates with neonatal hyperbilirubi-nemia admitted to our hospital from January 2022 to December 2022 and 48 healthy neonates who underwent physical examination during the same period were retrospectively analyzed.According to the serum total bilirubin(TBIL)level,the patients were divided into four groups:mild group(n=74),moderate group(n=53),severe group(n=64)and control group(n=48).The levels of TBIL,alanine aminotransferase(ALT),aspartate amin-otransferase(AST),γ-glutamyltransferase(GGT),alkaline phosphatase(ALP),lactic dehydrogenase(LDH)and hydroxybutyrate dehydrogenase(HBDH)in the mild,moderate and severe groups and the control group were detected.The liver function indexes(ALT,AST,ALP,GGT,LDH,HBDH)of the four groups were statistical-ly analyzed,and Pearson correlation analysis was performed between the liver function indexes and the level of TBIL.Results:There were significant differences in liver function indexes among the mild,moderate,severe groups and the control group(P＜0.05).The levels of AST,GGT,ALP,LDH,HBDH in the moderate group were significantly higher than those in the control group(P＜0.05).The levels of ALT,AST,GGT,LDH and HBDH in the severe group were significantly higher than those in the mild group(P＜0.05),and the levels of AST and HBDH in the severe group were significantly higher than those in the moderate group(P＜0.05).ALT,AST,GGT,LDH and HBDH were positively correlated with TBIL level(P＜0.05),while ALP was not correla-ted with TBIL level(P＞0.05).Conclusion:In newborn children with high blood bilirubin,different levels of bili-rubin may cause a certain degree of damage to the liver function.The higher bilirubin level,the deeper the degree of liver damage.So it need to pay close attention to the patient's liver function indicators,monitoring the progress of the disease,carry out the corresponding treatment measures timely and accurately.
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