Study on correlation between four new coagulation factors and renal function during red blood cell transfusion therapy in patients with acute myeloid leukemia
Objective:To analyze the relationship between the four new coagulation factors and renal function during red blood cell transfusion therapy in the patients with acute myeloid leukemia(AML).Methods:96 AML patients admitted to Department of Hematology of Shaanxi Provincial People's Hospital from June 2019 to May 2022 were selected as the study subjects,all receiving red blood cell transfusion therapy,with acute kidney injury(AKI)occurring during the treatment period as the endpoint event.After admission,blood samples were collected to test the patient's blood routine,coagulation,new coagulation,renal function,and general information.Based on the examination results,the relationship between new coagulation and AKI during red blood cell transfusion therapy in AML patients was analyzed.Results:96 patients with AML were selected in this study,4 patients with ineffective red blood cell transfusion,2 patients with grade Ⅳ Bone marrow suppression,and 90 patients were finally selected as the final study subjects.90 patients underwent red blood cell infusion for 13.00(11.75,14.00)weeks,and 22 patients(24.44％)developed AKI during red blood cell transfusion therapy.The number and amount of red blood cell transfusion in AKI patients were higher than those in N-AKI patients,the expression of plasma thrombomodulin(TM),tissue type plasmin activator inhibitor 1 complex(t-PAIC)and plasma cystatin C(CysC)were higher than those in N-AKI patients,and the expression of plasma thrombin antithrombin complex(TAT)and plasmin a2 plasmin inhibitor complex(PIC)were lower than those in N-AKI patients,with a statisti-cal significant difference(P＜0.05).Logistic regression analysis showed that the number of red blood cell transfu-sions,the up-regulation of plasma TM and t-PAIC expression were independent factors for AKI during red blood cell transfusion in AML patients(P＜0.05).The ROC curve was drawn,and plasma TM and t-PAIC in the new coagulation four items could predict the occurrence of AKI during red blood cell transfusion therapy in AML patients.Conclusion:Upregulation of plasma TM and t-PAIC expression in the four new coagulation factors may be a risk factor for AKI in AML patients during red blood cell transfusion therapy.Detection of plasma TM and t-PAIC before red blood cell transfusion therapy could help predict the occurrence of AKI.
acute myeloid leukemiared blood cell transfusion therapyacute kidney injurycoagulation function
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