Clinical significance of Rh phenotype detection and antibody screening in blood transfusion safety
To analyze the clinical significance of Rh antigen typing detection and irregular antibody for the in-compatibility in blood cross matching to ensure the safety of blood transfusion,a total of 7 939 blood donors'sam-ples were detected by Rh blood group antigen test card to establish Rh phenotype database.A total of 876 irregu-lar antibody screening positive patients were tested to identify antibody specificity.As a result,in these 7 939 samples with RhD positive blood group,eight kinds of Rh blood group phenotypes were detected.In the 904 pa-tients with irregular antibody screening positive,531 cases(58.74％)were in Rh system.809 samples(89.49％)were single antibody and 67 cases(7.41％)were mixed antibody,20 cases(2.21％)were autoantibodies and 8 ca-ses(0.89％)were mimicking antibodies.Of 67 mixed antibodies,64 cases were in Rh system combined with oth-er blood group system antibodies,accounting for up to 95.52％.Consequently,establishment of Rh phenotype database of patients and blood donors and blood transfusion with the same phenotype may reduce the production of Rh antibodies,increase the rate of compatibility and promote the safety of blood transfusion.
Rh antigenic typingirregular antibodyantibody identificationincompatibility in blood cross matching
NETL
NSTL
万方数据
