Clinical features of adult early T-cell precursor acute lymphoblastic leukemia
Objective:To summarize and analyze the clinical characteristics,treatment outcomes,and long-term prognosis of adult early T-cell precursor acute lymphoblastic leukemia(ETP-ALL).Methods:A retrospec-tive study was conducted on 15 ETP-ALL patients diagnosed and treated from April 2020 to December 2023.The relationships between basic clinical characteristics,immunophenotyping,cytogenetic and molecular biological ab-normalities,treatment regimens,and prognosis were analyzed.Results:The incidence of ETP-ALL among adult T-cell acute lymphoblastic leukemia patients was 21.8％,with 73.3％being male,a median age of 43 years,and a median percentage of bone marrow blast cells of 71.1％.Positive expressions of myeloid/stem cell antigens in-cluded CD34,CD117,HLA-DR,CD13,CD33,etc.22.2％of patients had chromosomal abnormalities,and 80.0％of patients had molecular biology abnormalities,with common gene mutations including NOTCH1,PHF6,JAK3,ETV6,JAK1,WT1,etc.After the first course of induction therapy,73.3％of patients achieved complete remission,and 66.7％achieved minimal residual disease negative complete remission.The median fol-low-up time was 15.4 months,with 1-year and 2-year overall survival rates of 90.9％and 77.9％,and 1-year and 2-year relapse-free survival rates of 86.2％and 64.6％,respectively.Conclusion:Adult ETP-ALL presents with both lymphoid and myeloid characteristics.Adding myeloid chemotherapy drugs or multiple targeted therapies to the VDCLP regimen may improve complete remission rates,and performing allogeneic hematopoietic stem cell transplantation as soon as possible during the first complete remission period may prolong the survival.
early T-cell precursorsacute lymphoblastic leukemiaclinical characteristicstreatment
NETL
NSTL
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