Clinical observation of anti-thymocyte globulin/anti-lymphocyte globulin in allogeneic stem cell transplantation
Objective:To observe the clinical efficacy and adverse events of anti-thymocyte globulin(ATG)/an-ti-lymphocyte globulin(ALG)in allogeneic stem cell transplantation.Methods:The clinical data of 36 patients with hematologic malignancies who received allogeneic stem cell transplantation in our hospital from January 2015 to April 2021 were retrospectively analyzed.The clinical data of patients included age,basic disease,sex,donor type,match degree,mononuclear cell counts,CD34 counts and preparative regimen.According to the pretreat-ment scheme,patients were divided into ATG group and ALG group,with 11 cases in the ATG group and 25 ca-ses in the ALG group.The implantation of granulocytes and platelets,the occurrence of acute and chronic graft versus host disease(GVHD),the survival of patients and the virus infection after transplantation in the two groups were observed.Results:The median follow-up time was 26.4(range 2.0 to 71.3)months.The median survival time of ATG group and ALG group was 32.9(range 9.0 to 41.0)months and 38.0(range 5.0 to 71.3)months,respectively,and there was no significant difference(P=0.44).By the end of follow-up,the duration of neutro-phils implantation in ALG group and ATG group was 13.4 days and 13.3 days,respectively,and there was no significant difference(P=0.30).The mortality in ATG group and ALG group was 27.3％and 36.0％,respec-tively,and there was no significant difference(P=0.47).The virus infection rates of ALG group and ATG group were 12.0％and 18.2％,respectively,and there was no significant difference(P=0.63).The rates of acute GVHD in ALG group and ATG group were 44.0％and 45.5％,respectively,and there was no significant differ-ence(P=1.00).The rates of chronic GVHD in ALG group and ATG group were 44.0％and 18.2％,respective-ly,and there was no significant difference(P=0.26).Conclusion:The efficacy of ALG in allogeneic stem cell transplantation is similar to that of ATG.However,the incidence of chronic GVHD in ALG group is higher than that of ATG group,but there is no significant difference.
anti-thymocyte globulin/anti-lymphocyte globulinallogeneic hematopoietic stem cell transplan-tationacute graft versus host diseasechronic graft versus host diseasehematological malignancy
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