非血缘脐血移植后兼有温冷双抗体Evans综合征1例并文献复习
Evans syndrome with both warm and cold antibodies after umbilical cord blood transplantation:a case report and literature review
时月 1孙艳花 2李乾鹏 2徐曼 2刘昊东 1冉学红2
作者信息
- 1. 山东第二医科大学(临床医学院)(山东潍坊,261000)
- 2. 潍坊市人民医院血液科
- 折叠
摘要
Evans综合征国内外报道较为少见,兼有温冷双抗体Evans综合征更为罕见.文章报道了 1例重型再生障碍性贫血患者行首次非血缘脐血移植后发生植人失败,再次输入非血缘脐血植入后病毒感染下引发兼有温冷双抗体Evans综合征,给予利妥昔单抗联合血浆置换治疗后患者各项指标均明显好转.笔者建议对于移植后早期并发Evans综合征的患者在给予传统方案治疗效果差时,应尽早考虑血浆置换和利妥昔单抗的联合和序贯应用.
Abstract
Reports on Evans syndrome are relatively rare at home and abroad,and Evans syndrome with both warm and cold antibodies is even rarest.We reported a case of severe aplastic anemia patient who had implantation failure after the first umbilical cord blood transplantation,and the second umbilical cord blood transplantation caused Evans syndrome with both warm and cold antibodies due to virus infection.After giving rituximab com-bined with plasma exchange,all the indexes were significantly improved.The authors suggest that the combina-tion and sequential use of plasma exchange and rituximab should be considered as early as possible in patients with Evans syndrome who have not responded well to conventional therapy.
关键词
非血缘脐血移植/Evans综合征/重型再生障碍性贫血/血浆置换/利妥昔单抗Key words
umbilical cord blood transplantation/Evans syndrome/severe aplastic anemia/plasma exchange/rituximab引用本文复制引用
出版年
2024
NETL
NSTL
万方数据