胃肠道急性移植物抗宿主病发病机制研究进展
Advances in pathogenesis of gastrointestinal tract acute graft versus host disease
李季哲 1蒋艺枝 1黄东平1
作者信息
- 1. 皖南医学院第一附属医院血液内科(安徽芜湖,241000)
- 折叠
摘要
异基因造血干细胞移植(allogeneic hematopoietic stem cell transplantation,allo-HSCT)是治疗恶性血液病的主要方法之一,胃肠道急性移植物抗宿主病(acute graft versus host disease,aGVHD)作为移植后较高的非复发死亡率的主要原因而直接影响患者的生存时间.其中T细胞生物学行为的改变会影响allo-HSCT受者免疫重建过程而诱导aGVHD的发生,而肠道微生物的稳态则可以保护胃肠道黏膜,在移植后免疫重建过程中增加受者的免疫力.本文从allo-HSCT后T细胞以及肠道微环境的变化、脂肪酸和细胞因子等生物标志物影响aGVHD的角度,综合阐述了胃肠道aGVHD的发病机制,进一步为allo-HSCT后肠道aGVHD的预防与治疗提供了临床思路.
Abstract
Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is one of the major methods for the treatment of hematopathy malignancies.Acute graft versus host disease(aGVHD)of the gastrointestinal tract as the main cause of high non-relapse mortality after allo-HSCT,directly affects the survival time of the patients.Changes in the biological behavior of T cells can influence the immune reconstitution process of allo-HSCT recipi-ents and induce aGVHD,whereas the gut microbial homeostasis can protect the gastrointestinal mucosa,and it can increase the recipients'immunity during the course of immune reconstitution after allo-HSCT.In this paper,the pathogenesis of gastrointestinal tract aGVHD was reviewed from the perspective of changes of T cells and in-testinal microenvironment after allo-HSCT,and the effect of biomarkers such as fatty acids and cytokines on aGVHD,in order to provide a new approach for the prevention and treatment of gastrointestinal tract aGVHD af-ter allo-HSCT.
关键词
异基因造血干细胞移植/胃肠道急性移植物抗宿主病/肠道微环境/T细胞/细胞因子Key words
allogeneic hematopoietic stem cell transplantation/gastrointestinal tract acute graft versus host disease/gut microenvironment/T cell/cytokine引用本文复制引用
基金项目
芜湖市科技计划(2022jc54)
国家自然科学基金青年科学基金(82200146)
国家卫生健康委血栓与止血重点实验室开放基金(KJS2273)
安徽省高等学校优秀青年项目(2022AH030121)
安徽省重点研发计划(202104j07020020)
皖南医学院弋矶山医院引进人才专项科研启动基金(YR202215)
出版年
2024
NETL
NSTL
万方数据