The current status of diagnosis and treatment of human parvovirus B19 infection after allogeneic hematopoietic stem cell transplantation
Human parvovirus B19(HPVB19)belongs to the parvoviridae family,erythroparvovirus,which is responsible for a variety of human diseases and is one of the important causes of refractory anemia after allogeneic hematopoietic stem cell transplantation(allo-HSCT).The most common clinical manifestations of HPVB19 infec-tion after allo-HSCT is anemia with decreased reticulocyte count,which can progress to pure red cell aplasia,but it also can be accompanied by leukopenia and thrombocytopenia,rash,arthralgia,myocarditis,hepatitis,pneu-monia,etc.The diagnosis of HPVB19 infection mainly depends on nucleic acid testing.Intravenous immunoglob-ulin and immunosuppressant dose reduction are effective treatments.HPVB19 infection has a good prognosis but a high recurrence rate.This article reviews the clinical features and diagnosis and treatment of HPVB19 infection in patients after allo-HSCT.
HPVB19allogeneic hematopoietic stem cell transplantationpure red cell aplasia
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