Study on the relationship between COVID-19 infection and plasma fibronectin and coagulation function in blood donors
Objective:To investigate the relationship between plasma fibronectin(pFN)and coagulation func-tion in blood donors infected with COVID-19.Methods:A total of 82 blood donors who donated blood at the blood center from December 1,2022 to January 31,2023 were selected as the study subjects.They were divided into two groups:the non-infected group(35 cases)and the infected-recovered group(47 cases)according to whether they were infected with COVID-19 and whether they had recovered.Samples were collected to test pFN,blood routine,coagulation factor Ⅷ(FⅧ)and coagulation function which included prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT),fibrinogen(Fib),and D-Dimer(D-D).The independent sample t-test was used to compare the changes in pFN and coagulation function between the two groups.Results:The pFN of the non-infected group and the infected-recovered group were(282.9±156.00)mg/L and(197.80± 96.95)mg/L,respectively.There was a significant difference between the two groups(P＜0.05).T he platelet count,PT,TT,APTT,Fib and D-D values of both groups were within the normal range,and the difference was not statistically significant(P＞0.05).Conclusion:For mild COVID-19 patients who had recovered,pFN con-sumption may increase,mainly participating in the body's immune inflammatory response,with little effect on co-agulation function,whose blood can meet the standard of Quality Requirements for Whole Blood and Blood Com-ponents(GB 18469-2012).
COVID-19blood donorsfibronectincoagulation function
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