摘要
目的:探讨感染新型冠状病毒疾病(COVID-19)与献血者的血浆纤维连接蛋白(pFN)和凝血功能的关系.方法:选取2022年12月1日-2023年1月31日在血液中心捐献血液的献血者82例为研究对象,根据是否感染COVID-19及感染康复分为未感染组(35例)和感染康复组(47例).留取标本检测pFN、血常规、凝血因子Ⅷ(FⅧ)、凝血功能[凝血酶原时间(PT)、凝血酶时间(TT)、活化部分凝血酶时间(APTT)、纤维蛋白原(Fib)及D-二聚体(D-Dimer,D-D)].采用独立样本t检验,比较2组pFN和凝血功能的变化.结果:未感染组及感染康复组的pFN分别为(282.90±156.00)mg/L和(197.80±96.95)mg/L,2组比较差异有统计学意义(P＜0.05).2组的血小板计数、PT、TT、APTT、Fib、D-D值均在正常范围内,差异无统计学意义(P＞0.05).结论:轻症感染COVID-19康复患者pFN消耗增加,主要参与机体免疫炎症反应,对凝血功能的影响较小,血液符合《全血及成分血质量要求(GB 18469-2012)》的标准.
Abstract
Objective:To investigate the relationship between plasma fibronectin(pFN)and coagulation func-tion in blood donors infected with COVID-19.Methods:A total of 82 blood donors who donated blood at the blood center from December 1,2022 to January 31,2023 were selected as the study subjects.They were divided into two groups:the non-infected group(35 cases)and the infected-recovered group(47 cases)according to whether they were infected with COVID-19 and whether they had recovered.Samples were collected to test pFN,blood routine,coagulation factor Ⅷ(FⅧ)and coagulation function which included prothrombin time(PT),thrombin time(TT),activated partial thromboplastin time(APTT),fibrinogen(Fib),and D-Dimer(D-D).The independent sample t-test was used to compare the changes in pFN and coagulation function between the two groups.Results:The pFN of the non-infected group and the infected-recovered group were(282.9±156.00)mg/L and(197.80± 96.95)mg/L,respectively.There was a significant difference between the two groups(P＜0.05).T he platelet count,PT,TT,APTT,Fib and D-D values of both groups were within the normal range,and the difference was not statistically significant(P＞0.05).Conclusion:For mild COVID-19 patients who had recovered,pFN con-sumption may increase,mainly participating in the body's immune inflammatory response,with little effect on co-agulation function,whose blood can meet the standard of Quality Requirements for Whole Blood and Blood Com-ponents(GB 18469-2012).
基金项目
江苏省卫生健康委员会重大科研项目(ZDA2020024)
NETL
NSTL
万方数据