Relationship between neutrophil levels and recurrence after high-dose dexamethasone treatment in patients with primary immune thrombocytopenia
Objective:To analyze the relationship between neutrophil levels and recurrence after high-dose dex-amethasone treatment in patients with primary immune thrombocytopenia(ITP).Methods:A total of 100 1TP pa-tients who received high-dose dexamethasone treatment in the department of hematology of our hospital from Oc-tober 2018 to April 2022 were included in the study.The recurrence of ITP patients after effective treatment was counted,and the patients were divided into recurrence group and non-recurrence group.The neutrophil levels at baseline and the last treatment of the two groups were measured,and the relationship between neutrophil levels and recurrence of ITP patients after high-dose dexamethasone treatment was analyzed.Results:According to sta-tistics,among 100 ITP patients who achieved effective treatment with high-dose dexamethasone,16 cases experi-enced recurrence,with a recurrence rate of 16.00％.The percentage of neutrophils in the two groups during the last treatment was higher than the baseline level,and the difference was statistically significant(P＜0.05).The percentage of neutrophils in the recurrence group at baseline and the last treatment was lower than that in the non recurrence group,and the difference was statistically significant(P＜0.05).Confirmed by point two column cor-relations,the percentage of neutrophils at baseline and final treatment was negatively correlated with recurrence in ITP patients after high-dose dexamethasone treatment(r＜0,P＜0.05).According to restricted cubic spline(RCS)analysis,there was a non-linear dose-response relationship between baseline neutrophil levels and recur-rence after high-dose dexamethasone treatment in ITP patients.When the baseline neutrophil percentage was less than 55.50％,the risk of recurrence after high-dose dexamethasone treatment gradually increased as the indicator level decreased.Conclusion:Neutrophil levels were associated with recurrence in ITP patients after high-dose dex-amethasone treatment.High baseline neutrophil levels in patients may indicate a higher risk of recurrence in ITP patients after high-dose dexamethasone treatment,and special attention should be paid.
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