The relationship between thioredoxin 1 and short-term adverse cardiac events in septic cardiomyopathy
Objective:To analyze the relationship between thioredoxin(Trx)-1 and the occurrence of short-term major adverse cardiac events(MACE)in septic cardiomyopathy.Methods:A total of 135 patients with septic cardiomyopathy who received treatment in emergency intensive care unit(EICU)of hospital from March 2020 to February 2023 were included and analyzed.135 patients underwent routine blood tests and data evaluation upon admission,with MACE occurring within 28 days of admission as the study end point.The patients were divided in-to the MACE group and the non MACE(N-MACE)group.logistic regression and restricted cubic spline method were used to analyze the relationship between serum Trx-1 and short-term MACE in septic cardiomyopathy.Results:Among the 135 patients with septic cardiomyopathy in this study,a total of 52 cases of MACE occurred within 28 days of admission,with an average occurrence time of(13.83±5.52)days and an incidence rate of 38.52％,ranging from 4 to 25 days.The MACE group had higher body temperature＞38.3 ℃,a higher propor-tion of chronic kidney disease(CKD),higher acute physiological and chronic health scores(APACHE Ⅱ),and higher levels of N-terminal precursor brain natriuretic peptide(NT-proBNP),interleukin-6(IL-6)and Trx-1 levels compared to the N-MACE group.The 24-hour lactate clearance rate and left ventricular ejection fraction(LVEF)were lower than those of N-MACE group,and the differences were statistically significant(P＜0.05).Logistic regression analysis showed that body temperature higher than＞38.3 ℃,APACHE Ⅱ score increased,insufficient lactate clearance,LVEF decreased,abnormal increase of serum Trx-1 and IL-6 levels were related to the increased risk of MACE in patients with septic cardiomyopathy within 28 days of admission(P＜0.05).The restricted cubic spline method showed that there was the positive linear relationship between serum Trx-1 and the risk of MACE within 28 days of admission in patients with septic cardiomyopathy(P＜0.05).Conclusion:The abnormal in-creased in serum Trx-1 levels in patients with septic cardiomyopathy was related to the occurrence of MACE with-in 28 days of admission,and the risk of MACE increased with the increase in serum Trx-1 levels.
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