Relationship of Hcy,β2-MG and hematopoietic score system and prognosis in patients with multiple myeloma
Objective:To analyse the relationship between Hey,β2-microglobulin(β2-MG)and the hematopoi-etic scoring system and the prognosis of patients with multiple myeloma(MM)patients,and evaluate the value of predicting the prognosis with them.Methods:The 100 patients with multiple myeloma admitted to the hospital from January 2017 to February 2020 were divided into survival group(66 patients)and death group(34 patients),and into ISS Ⅰ(35 patients),ISS Ⅱ(30 patients)and ISS Ⅲ(35 patients)according to the international staging system(ISS).The general data of patients including Hcy,β2-MG and the hematopoietic scoring systems were compared in different prognosis groups,and Hcy,β2-MG and the hematopoietic scoring systems were compared in different prognosis groups,and patients with different ISS stages.Results:The comparsion of the group with good prognosis and the group with poor prognosis in gender,body mass index(BMI),hypertension,diabetes,smoking history,alcohol history,bone marrow plasma cells,hemoglobin(Hb),blood calcium(Ca)and blood cre-atinine(Scr)level was not statistically different(P＞0.05).The age of the group with good prognosis was lower than the group with poor prognosis(P＜0.05).The Hey and β2-MG in serum of ISS stage Ⅰ group was lower than those of ISS stage Ⅱ group and ISS stage Ⅲ group(P＜0.05).The Hcy and β2-MG in serum of ISS stageⅡ group was lower than those of ISS stage Ⅲ group(P＜0.05).The proportion of score ≥1.5 of ISS Ⅰ was lower than that of ISS Ⅱ and ISS Ⅲ(P＜0.05).The proportion of score ≥1.5 of ISS Ⅱ was lower than that in the ISS Ⅲ(P＜0.05).The Hcy and β2-MG in the survival group was lower than those of the death group(P＜0.05),the proportion of score ≥1.5 in the survival group was lower than that in the death group(P＜0.05).Logistic regression analysis showed that age,Hcy,β2-MG and the hematopoietic scoring system were the factors affecting the poor prognosis in patients with multiple myeloma(P＜0.05).The area under the ROC curve for Hcy,β2-MG and the hematopoietic scoring system alone predicting the prognosis of patients with multiple myelo-ma were 0.883(0.807-0.959),0.887(0.822-0.951),0.762(0.702-0.865),the sensitivities were 0.852,0.867,and 0.895,the specificities were 0.855,0.830,and 0.816,respectively.The area under the ROC curve of the Hcy,β2-MG and the hematopoietic scoring system combined to predict the prognosis of patients with multiple myeloma was 0.928(0.877-0.979),the sensitivity was 0.908,and the specificity level was 0.810.Conclusion:The prognosis of multi-ple myeloma might be closely related to serum Hcy,β2-MG level and hematopoietic scoring system,and the combination of Hcy,β2-MG and hematopoietic scoring system might have higher prediction value than alone.
homocysteineβ2 microglobulinhematopoietic scoring systemmultiple myelomainternational staging system
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