Study on influencing factors of ineffective platelet transfusion in patients with tumor in Xinjiang
Objective:To investigate the influencing factors of ineffective platelet infusion in tumor patients in Xinjiang and further analyze the prognosis of patients with tumor after ineffective platelet infusion.Methods:135 patients with platelet transfusion from May 2021 to September 2021 were collected.According to CCI index,the patients were divided into effective group(n=85)and ineffective group(n=50).After collecting medical history data,CD36 on platelet surface,CD36 on lymphocytes surface,anti-HLA-Ⅰ antibody and HPA antibody were de-tected respectively,and the results were compared and analyzed.Two years after blood transfusion,the survival status of the patients was followed up by telephone.The survival curve was drawn by Kaplan-Meier method.Re-sults:There were significant differences in the number of blood bags,the validity period of platelet transfusion and the filtration of leukocytes between the effective group and ineffective group(P＜0.05).There was significant difference in the expression of CD36 antigen between the two groups(P=0.033),and there was significant differ-ence in the positive rate of platelet antibody in the patients with different types of platelet antibody(P＜0.001).The survival rate of leukemic patients with effective platelet infusion was significantly higher than that of ineffec-tive platelet infusion(P＜0.05).Conclusion:The incidence of ineffective platelet infusion in tumor patients in Xin-jiang was higher than that in other diseases.CD36,platelet antibody,platelet validity period and the number of blood transfusion bags in the past were the influencing factors of platelet infusion inefficacy in tumor patients.The ineffective platelet infusion in leukemia patients had a certain effect on the life cycle of leukemia patients.
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