Analysis of results of screening weak positive irregular antibodies by microcolumn glass bead method
To analyze the characteristics and distribution of weak positive irregular antibodies,and explore strategies to improve the detection of such antibodies.Retrospective analysis of 5 117 irregular antibody screening samples from December 2019 to March 2023,of which 55 samples showing weak positivity(agglutination strength≤1+)in irregular antibody screening were included in the study.Antibody specificity identification was performed on weak positivity samples,and the distribution relationship between gender,blood transfusion histo-ry,pregnancy history,different media,departments,and diseases was analyzed.The detection rate of weak posi-tive specimens was 1.07％.Antibodies were detected in 28 cases(50.9％)of MNS blood group system,13 cases(23.6％)of Lewis blood group system,4 cases(7.3％)of Rh blood group system,1 case(1.8％)of Diego sys-tem and 2 case(3.6％)of cold antibody,and 7 cases(12.7％)of unclear specificity antibody;39 females(70.9％);31 cases(56.4％)had a history of pregnancy;48 cases(87.3％)had no history of blood transfusion;All weak positive irregular antibodies were detected in the anti human globulin medium,and 42 cases(76.4％)were detected in saline media;There were 42 surgical patients(76.4％)and 8 internal medicine patients(14.5％);20 operation patients(36.4％)and 14 pregnancy test patients(25.5％).The weak positive irregular antibodies de-tected are mainly distributed in MNS blood group system and Lewis blood group system.Attention should be paid to the irregular antibody screening of surgical patients and pregnant women.The combined method of microcol-umn glass bead and saline method can improve the detection rate of weak positive irregular antibodies.
irregular antibody screeningweak positive irregular antibodiesMNS blood group system anti-bodiesLewis blood group system antibodiesdistribution
NETL
NSTL
万方数据
