The application of demethylating drugs in acute myeloid leukemia
Acute myeloid leukemia(AML)is a kind of malignant clonal hematological disease originated from hematopoietic stem cells.It is characterized by impaired differentiation and abnormal proliferation of hematopoietic stem cells.It is the most common type of adult leukemia.A study on the global burden in 2020 further elaborated the disease burden of AML worldwide and revealed its extensive impact on population health.A large number of new treatment strategies and drugs have constantly emerged after years of development.AML includes abnormal DNA methylation pattern,which leads to global hypomethylation and local hypermethylation,both of which pro-mote the pathogenesis of AML.Therefore,demethylated drugs have been introduced into the treatment strategy.Demethylated drugs have become an important part of AML treatment by changing the gene expression mode of tumor cells and promoting the differentiation and death of tumor cells,marking the development of treatment methods towards a more accurate direction.
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