Therapeutic application of sorafenib in acute myeloid leukemia
With the emergence of a variety of targeted drugs,acute myeloid leukemia(AML)has gradually entered an era of targeted therapy.As a multikinase inhibitor,mainly targeting FLT3-ITD,sorafenib is widely used in the treatment of AML,and it is mainly used for FLT3-ITD mutated AML,especially for the maintenance therapy after allogeneic hematopoietic stem cell transplantation.Besides,based on its multikinase inhibition,man-y studies have also tried to use sorafenib for the treatment of AML with FLT3-WT.Therefore,this review sum-marizes the therapeutic application and the progress of sorafenib in AML with FLT3-ITD mutation or FLT3-WT.
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