Investigation and analysis of ABO,Rh,Kidd,Kell blood group characteristics in patients with coronary heart disease
Objective:To investigate the distribution characteristics of ABO,Rh,Kidd and Kell blood group system antigens in patients with coronary heart disease(CHD).Methods:Samples of 2 000 patients with CHD who met the inclusion and exclusion criteria were collected from the People's Hospital of Xinjiang Uygur Autono-mous Region.Major antigens of ABO,Rh,Kidd and Kell blood groups were identified,gene exons of RhD blood group negative phenotype were sequenced,and blood group distribution of CHD patients of different ethnic groups was statistically analyzed.Results:The proportion of ABO type O in CHD patients was 28.87％.Uyghur was A＞B＞O＞AB,and Kazakh tended to be the same as Uyghur.RhD negative samples were detected in 59 cases(3.32％),and the frequency was Uyghur＞Kazak＞Kirgiz＞Hui＞Other nationalities＞Mongolian.Thirteen Rh types were detected,the CcDEe of Kirgiz was 38.81％,and the phenotypic distribution of all ethnic groups was in line with Hardy-Weinberg equilibrium(P＞0.05).In the distribution of Rh genotype,the frequency of e gene was second only to D gene,while CDe genotype was the most common in the frequency of gene combinations.The gene sequencing of D-negative samples found a new mutation site,exon 5 g.712G＞A,and a heterozygous Del sample of RhD 1227A.The distribution of Jka and Jkb antigens in Kazakh population was up to 83.33％and 78.57％,and the frequency of Jk(a+b+)in Kazakh population was found to be 61.90％,and no Jk(a-b)phe-notype was detected.The positive K antigen was detected in 30 cases,accounting for 1.69％,the highest positive rate of Kirgiz was 2.24％.Conclusion:The distribution of ABO,Rh,Kidd and Kell blood group system antigens in patients with CHD of different nationalities has its own characteristics,which provides a basis for the detection of CHD before transfusion,clinical transfusion treatment and later disease correlation research.
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