Analysis of anti-TP detection in blood center laboratories
Objective:To understand the situation and characteristics of Treponema pallidum(TP)infection in the unpaid blood donation population of our center.Methods:Conduct statistical analysis on the confirmation re-sults of anti-TP ELISA dual-reagent reactive specimens from unpaid blood donors in our center in 2022.Results:In 2022,a total of 203 097 samples were detected from 165 876 blood donors.The unqualified rate of anti-TP ELISA screening was 0.16％(334/203 097),and the dual-reagent reaction rate was 0.10％(202/203 097).The positive rate of TPPA was 0.08％(167/203 097)and the estimated prevalence was about 0.10％(167/165 876).97.60％(163/167)of TPPA positive samples were gold standard positive.The confirmed positive rate of first-time blood donors(0.23％)was higher than that of repeated blood donors(0.02％)(P＜0.01),and the prevalence rate of female blood donors(0.13％)was slightly higher than that of male blood donors(0.08％)(P＜0.01).There was no significant difference in gender among first-time blood donors(P＞0.05).The positive rate was 0.26％for females and 0.21％for males.There was statistical difference in age group(P＜0.01),the lowest positive rate was found in 26-35 years old(0.16％),and the highest rate was found in 56-60 years old(0.87％).The annual rate of new TP infections among repeated donors was 0.01％.A total of 4 cases of TP with HIV in-fection were detected.Conclusion:The confirmed positive rate of syphilis among unpaid blood donors in Shiji-azhuang area was relatively low.In the absence of the conditions for the confirmatory test of TPPA,the dual-rea-gent reaction rate was used to estimate that the unqualified rate was closer to the true level of syphilis infection.If the anti-TP colloidal gold method was added to the pre-donation screening project,the vast majority of syphilis in-fections and some HIV-infected patients could be intercepted,and the unnecessary waste of resources could be re-duced.
NETL
NSTL
万方数据
