Analysis of therapeutic countermeasures for blood transfusion in patients with positive screening for irregular antibodies
Objective:To analyze the effectiveness of transfusions,adverse reaction rate and the time needed to match blood in the patients who tested positive in irregular antibody screening employing both blind screening and antibody identification blood matching procedures,and explore the clinical benefits of these two blood matching methods.Methods:All patients used the cross-matching methods in our hospital from January 2014 to November 2023 were retrospectively analyzed,specifically focusing on those with positive irregular antibody screening tests.The goal was to compare the efficacy of two methods in terms of transfusion effectiveness,adverse reaction rate and time required for blood matching.Results:Among 55 853 patients for cross-matching,297 cases returned positive results for irregular antibody screening test,with a positive rate of 0.53％.266 patients were cross-matched by blind screening,154 patients were transfused,and 1 case had an adverse reaction to blood transfusion;31 patients were cross-matched by antibody identification and classical anti-human globulin method,and 23 cases were transfused and no adverse reactions occurred.The time used for blind screening was(35.98±3.43)min,and the time used for blood matching after antibody identification was(321.60±75.77)min.Conclusion:Blind screening for cross-matching of patients with irregular positive antibody screening can save time and economic cost of blood matching,which is important for rescuing critically ill patients;however,there are risks associated with blind screening,and antibody identification and classical anti-human globulin line compatibility should be carried out as far as possible when the condition permits to ensure the maximum degree of transfusion safety.
positive screening for irregular antibodiescross-matchingblood transfusion effectadverse reactionsblood matching time
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