首页|心外术后采用血栓弹力图监测指导输血对心功能、凝血功能的影响

心外术后采用血栓弹力图监测指导输血对心功能、凝血功能的影响

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目的:分析心外术后采用血栓弹力图(TEG)监测指导输血对心功能、凝血功能的影响.方法:回顾性纳入医院2021年4月-2023年5月收治的100例行心外科手术治疗患者为研究对象,根据不同指导输血方式将其划分为对照组(常规心功能、凝血功能监测指导输血)与研究组(TEG监测指导输血),每组患者50例,分析输血前、输血24 h后对研究组患者TEG相关参数[凝血反应时间(R值)、凝血形成时间(K值)、凝血形成速率(a角)、凝血最大强度(MA)、凝血综合指数(CI)]的变化情况,比较不同指导模式下研究组与对照组间输血前及输血24 h后的心功能[左室收缩期内径(LVESD)、左室舒张末期内径(LVEDD)、左室射血分数(LVEF)]及凝血功能[活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)、纤维蛋白原(FIB)、凝血酶时间(TT)].结果:①研究组采用TEG指导输血24 h后,TEG指标K、R更低,α、MA、CI更高,差异有统计学意义(P<0.05);②输血前研究组与对照组间LVEDD、LVESD、LVEF比较,差异无统计学意义(P>0.05),输血24 h后,研究组与对照组LVEDD、LVESD均降低,LVEF均升高,组间比较差异有统计学意义(P<0.05),但研究组LVEF高于对照组,LVEDD、LVESD低于对照组,组间比较差异有统计学意义(P<0.05);③输血前研究组与对照组间TT、PT、APTT、FIB比较差异无统计学意义(P>0.05),输血24 h后,研究组及对照组TT、PT、APTT均下降,FIB均上升,组间比较差异有统计学意义(P<0.05),但研究组TT、PT、APTT低于对照组,FIB高于对照组,组间比较差异有统计学意义(P<0.05).结论:相较于传统凝血功能监测模式,TEG能实现动态实时监测,心外术后采用TEG监测指导输血能显著提升患者的心功能水平、改善患者凝血功能,保障心外术后患者输血的安全性,建议临床推广使用.
Effect of monitoring and guiding blood transfusion by TEG on cardiac function and coagulation function
Objective:To analyze the effect of guiding blood transfusion on cardiac function and coagulation function.Methods:A total of 100 patients admitted to cardiac surgery in our hospital from April 2021 to May 2023 were retrospectively included as the study object.According to different guiding blood transfusion methods,they were divided into control group(routine cardiac function and coagulation function monitor guide blood trans-fusion)and research group(thrombelastogram[TEG]monitor guide blood transfusion),of the 50 patients in each group.The TEG parameters of the study group were analyzed before and 24h after transfusion.The parameters were compared between study and control groups,including cardiac function(left ventricular end-diastolic diame-ter[LVEDD],left ventricular end-systolic diameter[LVESD],left ventricular ejection fraction[LVEF])and co-agulation function(prothrombin time[PT],activated partial thromboplastin time[APTT],fibrinogen[FIB],thrombin time[TT]).Results:①The study group performed TEG for 24 h after guiding blood transfusion,lower TEG indicators K,R,a,MA,and higher CI,statistically significant difference(P<0.05);②There was no sta-tistical significance of LVEDD,LVESD and LVEF between the study group and the control group(P>0.05).After 24 h of blood transfusion,LVEDD and LVESD in the study group and the control group were both de-creased,LVEF were both increased,there were statistical significance between the groups(P<0.05).However,LVEDD and LVESD in the study group were lower than those in the control group,the LVEF in the study group was higher than that in the control group,and there were statistically significant between the groups(P<0.05).③There was no statistical significance of TT,PT,APTT and FIB between the study group and the control group(P>0.05).After 24 h of blood transfusion,TT,PT and APTT decreased in the study and control groups,FIB both increased,and there was statistically significant difference(P<0.05).However,TT,PT and APTT in the study group were lower than those in the control group,FIB was higher than that in the control group,and there was statistically significant between the groups(P<0.05).Conclusion:Compared with the traditional coagulation function monitoring mode,TEG guiding blood transfusion could realize dynamic real-time monitoring,significant-ly improve the cardiac function level and coagulation function of patients,and ensure the safety of blood transfu-sion in patients after extracardiac surgery.

extracardiac surgerythrombelastogramblood transfusioncardiac functioncoagulation function

胡振男、刘广锋、李渊、李畅、邢陆陆

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徐州市肿瘤医院输血科(江苏徐州,221000)

心外术后 血栓弹力图 输血 心功能 凝血功能

2024

临床血液学杂志
华中科技大学同济医学院血液病研究所 北京医科大学血液病研究所

临床血液学杂志

CSTPCD
影响因子:1.063
ISSN:1004-2806
年,卷(期):2024.37(6)
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