Analysis of antibody identification results and efficacy and safety of transfusion in 286 patients with positive unexpected antibodies
Objective:To explore the distribution of positive unexpected antibodies in Guangxi districts,and evaluate the efficacy and safety of the corresponding transfusion strategies for patients with positive unexpected an-tibodies.Methods:A retrospective review of 286 cases of positive unexpected antibodies recorded in our hospital during July 2021 to September 2023 was performed.The patients were divided into three groups according to the corresponding transfusion strategy including non-reactive cross-matching test with negative antigen phenotype(35 cases),and non-reactive cross-matching test without antigen phenotype(11 cases),and positively reactive cross-matching test with the strength of agglutination no higher than those of auto-control(9 cases).Blood routine and biochemical data before and after transfusion were simultaneously collected,then the increment values of he-moglobin per unit of red blood cell and altered values of total and indirect bilirubin after transfusion were analyzed to evaluate the efficacy and safety of transfusion.Results:① The age distribution of 286 patients with positive un-expected antibody was(44.21±23.02)years old,including 134 males and 152 females(ratio:0.88∶1.00);The Han nationality(62.8％)and Zhuang nationality(32.1％)were the main groups.Most patients suffered from he-matologic diseases(45.1％),neoplastic diseases(14.0％),digestive diseases(9.8％),and cardiovascular diseases(7.0％).②A total of 233 blood group-specific unexpected antibodies were identified,of which anti-E(34.29％),anti-Lea(10.45％),anti-M and anti-c(8.39％),anti-Mur(4.90％),anti-Jka and anti-C(2.45％).③The incre-mental value of Hb per unit of red blood cell(x2=2.142,P=0.343)and total bilirubin(x2=5.455,P=0.065)and indirect bilirubin(x2=2.716,P=0.257)had no significant difference among the three transfusion strategies groups.Conclusion:Unexpected antibodies of Guangxi districts were mainly found in Rh,MNS and Lewis blood group system.Accurate antibody identification was important for guiding safe blood transfusion for patients with positive unexpected antibodies.
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