Exploring the prevention status of venous thromboembolism in Chinese multiple myeloma based on single-center real-world data and the predictive value of related risk stratification systems
Objective:To investigate the prevention measures and occurrence of venous thromboembolism(VTE)in patients with multiple myeloma(MM)based on real-world data.It examines the existing issues in VTE prevention in Chinese MM patients and preliminarily tests the predictive efficacy of the VTE risk score system proposed in the Consensus on the Prevention and Treatment of Venous Thromboembolism in Multiple Myeloma in China(2022 Edition),referred to as the Chinese Consensus Risk Score System,for the occurrence of VTE in newly diagnosed multiple myeloma(NDMM)patients in China.Methods:Clinical data of NDMM patients diag-nosed at our hospital between January 2018 and August 2023 was collected and analyzed,including patients'base-line characteristics,VTE prophylactic medications,and the occurrence of VTE.Patients were assessed for risk u-sing the Chinese Consensus Risk Score System,and the incidence of VTE will be calculated.The predictive effec-tiveness of the system was compared with the IMPEDE model using the area under the receiver operating charac-teristic curve.Results:Among 428 NDMM patients,the incidence of VTE was 9.58％.The VTE incidence in the low-risk,high-risk,and very high-risk groups was 3.35％,26.60％,and 40.00％,respectively.There was a statistically significant difference in VTE incidence between the low-risk group and the high-risk/very high-risk group(P＜0.05).In the low-risk group,170 patients received thromboprophylaxis,with 164 using aspirin and 6 using anticoagulants.In the high-risk group,60 patients received thromboprophylaxis,with 57 using aspirin and 3 using anticoagulants.The proportion of patients using aspirin was 68.62％and 60.64％in the low-risk and high-risk groups,respectively.The Chinese Consensus Risk Score System and the IMPEDE model had receiver operat-ing characteristic(ROC)curve areas under the curve(AUC)of 0.760(0.670-0.850)and 0.685(0.591-0.780),respectively.The sensitivity was 70.70％and 73.20％,and the specificity was 80.60％and 59.40％,respectively.Conclusion:The Chinese Consensus Risk Score System can effectively differentiate low-risk,high-risk,and very high-risk patients,and it has better predictive efficacy than the IMPEDE model.The understanding of stratified prevention of MM-related VTE among Chinese hematologists needs further improvement,and rational prevention medication requires more exploration with clinical data.
万方数据
维普
