The prognostic significance of POD24 with Hodgkin lymphoma
Objective:To explore the effect of progression of disease within 24 months(POD24)on overall sur-vival(OS)of Hodgkin lymphoma(HL),compare to the clinical characteristics between POD24 HL with non-POD24 HL patients,and analyze the related risk factors affecting POD24.Methods:The patients with HL who were treated in the Affiliated Hospital of Xuzhou Medical University from January 2004 to August 2021 were ret-rospectively analyzed,and their prognosis and clinical characteristics were evaluated.Results:A total of 98 pa-tients with HL were included.The median OS and PFS of all patients were 75.3(25.0-228.0)months and 60.0(2.0-192.0)months,respectively.Among them,there were 27 patients in the POD24 group.The median OS and PFS of thePOD24 group were 52.0(25.0-160.0)months and 12.0(2.0-160.0)months,The median OS and PFS of the non-POD24 group were 84.0(25.0-228.0)months and 70.0(20.0-192.0)months respectively.Univa-riate analysis showed that POD24,albumin(＜40 g/L),hemoglobin(＜100 g/L),serum β2 microglobulin(＞2.366 mg/L),IPI score 0-2,treatment response after initial chemotherapy,age＞60 years,and Eastern Coopera-tive Oncology Group(ECGO)physical status(PS)score 0-1 were adverse prognostic factors associated with overall survival(OS).Multivariate analysis showed that POD24(P＜0.001),albumin(＜40 g/L)(P=0.011),age＞60 years(P=0.022)and remission after initial treatment(P=0.005)had independent prognostic significance.Ac-cording to the data of this group,63 patients in the non-POD24 group had remission after initial chemotherapy,while only 13 patients in the POD24 group.In addition,there were significant differences in Ann Arbor staging,IPI score,serum β2 microglobulin,and ECOG PS score between the POD24 group and the non-POD24 group(P＜0.05).Conclusion:POD24 is an independent poor prognostic factor for the OS of HL patients.The proportion of patients with Ann Arbor stage Ⅲ/Ⅳ and unresponsive disease after initial chemotherapy was higher in the POD24 group,while patients with IPI score 0-2 and ECGO score 0-1 have a lower proportion of POD24.
万方数据
维普
