Allogeneic hematopoietic stem cell transplantation with bone marrow derived mesenchymal stem cell co-infusion in Shwachman-Diamond syndrome with myelodysplastic syndrome:A case report and literature review
Shwachman-Diamond syndrome(SDS)is a rare,multi-systemic disorder with bone marrow failure,exocrine pancreatic insufficiency,and skeletal abnormalities.Bone marrow failure include severe aplastic anemia and myelodysplastic syndrome,some patients develop acute leukemia with poor prognosis.It reported a case of SDS with myelodysplastic syndrome successfully treated with allogeneic hematopoietic stem cell transplantation and bone marrow derived mesenchymal stem cell co-infusion.Allogeneic hematopoietic stem cell transplantation is a feasible and effective option for SDS patients with bone marrow failure.Early recognition of the disease and hematopoietic stem cell transplantation for SDS patients with bone marrow failure will improve survival.
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维普
