Progress in the study of CAR-T cell therapy in the treatment of hematological tumors of central nervous system
The central nervous system(CNS)is a common site of extramedullary invasion by hematological malignant tumors,and the involvement of the CNS is often closely related to poor prognosis.However,the exist-ing therapies and their curative effects are far from meeting the needs.CAR-T cell therapy has shown great advan-tages in the treatment of hematological tumors at home and abroad,but the treatment of CNS hematological tumors has been controversial due to the risk of neurotoxicity.Therefore,this article reviews some of the studies on CAR-T in the treatment of CNS hematological tumors,and discusses the possibility,safety and efficacy of the therapy in the treatment of CNS hematological tumors.The purpose is to provide a reference for clinical work and improve the remission rate and survival rate of such patients.
chimeric antigen receptor T cellscentral nervous systemhematological malignant tumor
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维普
