Predictive value of thromboelastography combined with conventional coagulation indexes in risk of hypercoagulation in lung cancer patients
Objective:To investigate the effect of thromboelastography(TEG)combined with conventional co-agulation on the detection of coagulation function and the prediction of hypercoagulability in lung cancer patients.Methods:A total of 100 lung cancer patients in our hospital from January 1,2021 to March 31,2023 were collect-ed from TEG and routine coagulation-related indicators,and were divided into hypercoagulable group(n=26)and non-hypercoagulation group(n=74)according to their coagulation status and clinical manifestations.At the same time,40 healthy individuals were selected as the control group to test TEG indicators:coagulation reaction time(R value),coagulation formation rate(Angle angle),maximum coagulation strength(MA),and conventional coagu-lation indicators:prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),D-dimer(D-D)and fibrinogen(FIB).Results:Compared with healthy patients,the Angle,MA,APTT,FIB,and D-D values of lung cancer patients increased,while the R value decreased.There were statistically significant differences in APTT,FIB,Angle and MA between the hypercoagulable group,non-hypercoagulable group and healthy group(P＜0.05).The correlation between TEG and the five conventional coagulation indexes was found in the hypercoagulable group,and the Angle angle was positively correlated with FIB(P＜0.05),and the MA val-ue was positively correlated with FIB(P＜0.05).The R value was positively correlated with PT(P＜0.05)and negatively correlated with FIB(P＜0.05).Analysis of receiver operating characteristic(ROC)curve by subject.The ROC area under the curve of lung cancer patients evaluated by combining TEG and conventional coagulation was 0.905,with a sensitivity of 0.932 and a specificity of 0.811.This was the best way to assess the patient's hy-percoagulability.Conclusion:Compared with the traditional four coagulation indexes,TEG can detect coagulation abnormalities in lung cancer patients faster and more accurately.In the hypercoagulable state,there was a correla-tion between conventional coagulation parameters and TEG parameters.Combined TEG and conventional coagula-tion indexes can help to detect coagulation abnormalities in lung cancer patients,predict the risk of hypercoagula-tion,and guide clinical medication to prevent the formation of thrombosis.
thromboelastographyroutine coagulation indexlung cancerhypercoagulable state
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