Value of lymphocyte subsets combined with immunoglobulin for diagnosis of Henoch-Schonlein purpura complicated by gastrointestinal symptoms in children
Objective:To explore the diagnostic value of lymphocyte subsets combined with immunoglobulin(Ig)in children with Henoch-Schonlein purpura complicated with gastrointestinal symptoms.Methods:The clini-cal data of 80 children with Henoch-Schonlein purpura treated in our hospital from December 2017 to December 2022 were retrospectively analyzed.According to the symptoms of Henoch-Schonlein purpura,the children were divided into a complicated group and a simple group.40 children with Henoch-Schonlein purpura complicated with gastrointestinal symptoms were assigned as the complicated group.Only 40 cases of pure purpura with skin pur-pura as the first symptom were set as the simple group.The general data,lymphocyte subsets,immunoglobulin were compared between the two groups,and the correlation between natural killer(NK)cell count,IgA,IgE,IgG levels and gastrointestinal symptoms of children with Henoch-Schonlein purpura was compared by Spearman method.Results:The NK cell count,IgA and IgG levels in the complicated group were significantly lower than those in the simple group(P＜0.05),and the IgE level was significantly higher than that in the simple group(P＜0.05).The NK cell count,IgA and IgG levels were negatively correlated with the gastrointestinal symptoms of Henoch-Schonlein purpura(P＜0.05).IgE level was positively correlated with Henoch-Schonlein purpura compli-cated with gastrointestinal symptoms(P＜0.05).The AUC values of NK cell count,IgA,IgE and IgG levels in the diagnosis of Henoch-Schonlein purpura complicated with gastrointestinal symptoms in children were 0.649,0.644,0.829 and 0.969,respectively(P＜0.05).Conclusion:Lymphocyte subsets combined with immunoglobu-lin may have a good diagnostic value for children with Henoch-Schonlein purpura complicated with gastrointestinal symptoms.The decrease of NK cell count,IgA and IgG levels,and the increase of IgE level may indicate children with henoch-Schonlein purpura complicated with gastrointestinal symptoms.
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