Analysis of influencing factors of blood transfusion complications in very low birth weight infants
Objective:To study the influence and factor analysis of blood transfusion on the incidence of com-mon complications in very low birthweight infants(VLBWI).Methods:A total of 361 VLBW children hospitalized in the neonatal intensive care unit from January 1,2020 to December 31,2022 were selected as the study subjects,including 324 VLBW children who received leucocyte suspended red blood cells(transfusion group)and 37 children who did not receive transfusion(non-transfusion group).The effects of blood transfusion on the complications of children were retrospectively analyzed,and the differences in the incidence of common complications of VLBWI between the transfusion group and the non-transfusion group were compared.The effects of the time of first transfusion and the number of transfusion on the complications of VLBWI and the risk factors of transfusion-relat-ed necrotizing enterocolitis(NEC)were analyzed.Results:The incidence of bronchopulmonary dysplasia(BPD),NEC,ventricular hemorrhage(IVH)and septicemia in VLBWI transfusion group was significantly higher than that in non-transfusion group(P＜0.05).The incidence of BPD,NEC and retinopathy of prematurity(ROP)after VLBWI transfusion were 72.53％,18.21％and 15.74％,respectively.The incidence of BPD,NEC,ROP and neonatal feeding intolerance in VLBWI early transfusion group(the first transfusion was within 2 weeks of birth)was significantly higher than that in late transfusion group(the first transfusion was after 2 weeks of birth)(P＜0.05),while the incidence of neonatal sepsis was not statistically significant(P＞0.05).The incidence of BPD,NEC,ROP,IVH,neonatal feeding intolerance and sepsis in ≥3 VLBWI transfusion group were significantly higher than those in＜3 transfusion group(P＜0.05).Multivariate logistic regression analysis showed that the number of transfusions was an independent risk factor for NEC(OR=1.211,95％CI 1.017-1.444,P=0.032).Conclusion:The incidence of VLBWI related complications may be related to blood transfusion.The earlier the first transfusion time and the more transfusions,the higher the incidence of related complications.Early blood transfusion and the number of transfusions should be reduced to reduce the occurrence of related complications.
very low birth weight infantsblood transfusioncomplication
NETL
NSTL
万方数据
