Methods of removing interference of CD38 monoclonal antibody in blood transfusion compatibility detection and literature review
Objective:To review the literatures on Daratumumab interfering the blood transfusion compatibili-ty testing,as well as ways to avoid these potential problems,and seek clinical and laboratory recommendations for the safety of blood transfusion practice.Methods:Using the polybrene or dithiothreitol(DTT)to treat red blood cells for blood transfusion compatibility testing.Results:Red blood cells treated with polybrene or DTT were used for blood transfusion compatibility testing,results of irregular antibody screening and identification were negative,and cross-matching was compatibility.Conclusion:The application of red blood cells treated with polybrene or DTT can remove the interference of Daratumumab in blood transfusion compatibility testing.
CD38monoclonal antibodyblood transfusion compatibility test
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