去除CD38单抗对输血相容性检测干扰的方法并文献复习
Methods of removing interference of CD38 monoclonal antibody in blood transfusion compatibility detection and literature review
张德峰 1孙胜君 2于淑红1
作者信息
- 1. 烟台毓璜顶医院输血科(山东烟台,264000)
- 2. 烟台市烟台山医院检验科
- 折叠
摘要
目的:回顾有关达雷妥尤单抗干扰输血相容性检测的文献,以及规避潜在问题的方法,并寻求为安全的输血实践提供临床和实验室建议.方法:采用聚凝胺或二硫苏糖醇(DTT)处理红细胞的方法,进行输血相容性检测.结果:聚凝胺或DTT处理后的红细胞用于输血相容性检测,不规则抗体筛查及鉴定结果为阴性,交叉配血试验相合.结论:聚凝胺或DTT处理红细胞的方法可以去除达雷妥尤单抗对输血相容性检测的干扰.
Abstract
Objective:To review the literatures on Daratumumab interfering the blood transfusion compatibili-ty testing,as well as ways to avoid these potential problems,and seek clinical and laboratory recommendations for the safety of blood transfusion practice.Methods:Using the polybrene or dithiothreitol(DTT)to treat red blood cells for blood transfusion compatibility testing.Results:Red blood cells treated with polybrene or DTT were used for blood transfusion compatibility testing,results of irregular antibody screening and identification were negative,and cross-matching was compatibility.Conclusion:The application of red blood cells treated with polybrene or DTT can remove the interference of Daratumumab in blood transfusion compatibility testing.
关键词
CD38/单克隆抗体/输血相容性检测Key words
CD38/monoclonal antibody/blood transfusion compatibility test引用本文复制引用
出版年
2024
NETL
NSTL
万方数据