The relationship between the proportion of peripheral blood primitive cells and the prognostic risk stratification in patients with chronic myelomonocytic leukemia
Objective:To analyze the correlation between the proportion of peripheral blood primitive cells and the prognostic risk stratification in patients with chronic myelomonocytic leukemia(CMML).Methods:The data of 80 CMML patients admitted to the Department of Hematology of Hospital from October 2017 to July 2023 were retrospectively analyzed.The proportion of peripheral blood blast cells before treatment was collected,and the patients were divided into low-risk group(20 cases),medium-risk group(42 cases)and high-risk group(18 ca-ses)according to the global M.D.Anderson prognostic score(MDAPS)after treatment.The relationship be-tween the proportion of peripheral blood primitive cells and the prognostic risk stratification of CMML patients was analyzed.At the same time,patients were divided into a＜5％group(36 cases)and a≥5％group(44 cases)based on the proportion of peripheral blood primitive cells.The survival outcomes of patients in the two groups were followed up and recorded,and the relationship between the proportion of peripheral blood primitive cells and the survival outcomes of CMML patients was analyzed.Results:There were significant difference in white blood cell count,peripheral primitive cell ratio,and hemoglobin in patients with different prognostic risk stratification(P＜0.05).According to Kendall's tau-b correlation test,white blood cell count,proportion of peripheral blood primitive cells,and prognosis risk of CMML patients were positively correlated,while hemoglobin was negatively correlated with prognosis risk stratification(P＜0.05).Following up for one year,the overall survival rate of 80 patients was 71.25％.The survival rates of the group with a ratio of＜5％and a ratio of ≥5％were 77.78％(28/36)and 65.91％(29/44),respectively.Log-rank x2 tests showed that the total survival time was significantly dif-ferent between the group with a ratio of＜5％of primitive cells and the group with a ratio of ≥5％of primitive cells([12.75±2.82]months vs[10.45±1.74]months,P＜0.05).Cox regression analysis showed that white blood cell count and peripheral blood primordial cell ratio were influencing factors for the survival outcome of CMML patients(P＜0.05),while other indicators had no significant impact on the survival outcome of CMML patients(P＞0.05).Conclusion:The proportion of peripheral blood primordial cells is related to the risk stratifica-tion of prognosis in CMML patients,and the higher the proportion of peripheral blood primordial cells before treatment,the worse the survival outcome.
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