外周血原始细胞比例与慢性粒单核细胞白血病患者预后危险度分层的关系探讨
The relationship between the proportion of peripheral blood primitive cells and the prognostic risk stratification in patients with chronic myelomonocytic leukemia
鲍文强 1金其川 1汪琼 2徐士云 1凌春1
作者信息
- 1. 滁州市第一人民医院血液科(安徽滁州,239000)
- 2. 黄山市人民医院血液科
- 折叠
摘要
目的:分析外周血原始细胞比例与慢性粒单核细胞白血病(CMML)患者预后危险度分层的相关性.方法:纳入医院血液科2017年10月至2023年7月收治的80例CMML患者资料进行回顾性分析,收集患者治疗前外周血原始细胞比例,治疗结束后参照全球M.D.安德森预后积分(MDAPS)将患者分为低危(20例)、中危(42例)和高危组(18例),分析外周血原始细胞比例与CMML患者预后危险度分层的关系.同时根据外周血原始细胞比例将患者分为＜5％组(36例)和≥5％组(44例),随访记录2组患者的生存结局,分析外周血原始细胞比例与CMML患者生存结局的关系.结果:不同预后危险度分层患者白细胞计数、外周原始细胞比例、血红蛋白比较,差异有统计学意义(P＜0.05).经Kendall's tau-b相关性检验,白细胞计数、外周血原始细胞比例与CMML患者预后危险度呈正相关,血红蛋白与预后危险度分层呈负相关(P＜0.05).随访1年,80例患者总生存率为71.25％,原始细胞比例＜5％组和原始细胞比例≥5％组生存率分别为77.78％(28/36)、65.91％(29/44).Log-rank x2检验显示,原始细胞比例＜5％组和原始细胞比例≥5％组总生存期比较,差异有统计学意义[(12.75±2.82)个月vs(10.45±1.74)个月,P＜0.05].Cox回归分析显示,白细胞计数、外周血原始细胞比例是CMML患者生存结局的影响因素(P＜0.05),其他指标对CMML患者生存结局无显著影响(P＞0.05).结论:外周血原始细胞比例与CMML患者预后危险度分层有关,且患者治疗前外周血原始比例越高,生存结局越差.
Abstract
Objective:To analyze the correlation between the proportion of peripheral blood primitive cells and the prognostic risk stratification in patients with chronic myelomonocytic leukemia(CMML).Methods:The data of 80 CMML patients admitted to the Department of Hematology of Hospital from October 2017 to July 2023 were retrospectively analyzed.The proportion of peripheral blood blast cells before treatment was collected,and the patients were divided into low-risk group(20 cases),medium-risk group(42 cases)and high-risk group(18 ca-ses)according to the global M.D.Anderson prognostic score(MDAPS)after treatment.The relationship be-tween the proportion of peripheral blood primitive cells and the prognostic risk stratification of CMML patients was analyzed.At the same time,patients were divided into a＜5％group(36 cases)and a≥5％group(44 cases)based on the proportion of peripheral blood primitive cells.The survival outcomes of patients in the two groups were followed up and recorded,and the relationship between the proportion of peripheral blood primitive cells and the survival outcomes of CMML patients was analyzed.Results:There were significant difference in white blood cell count,peripheral primitive cell ratio,and hemoglobin in patients with different prognostic risk stratification(P＜0.05).According to Kendall's tau-b correlation test,white blood cell count,proportion of peripheral blood primitive cells,and prognosis risk of CMML patients were positively correlated,while hemoglobin was negatively correlated with prognosis risk stratification(P＜0.05).Following up for one year,the overall survival rate of 80 patients was 71.25％.The survival rates of the group with a ratio of＜5％and a ratio of ≥5％were 77.78％(28/36)and 65.91％(29/44),respectively.Log-rank x2 tests showed that the total survival time was significantly dif-ferent between the group with a ratio of＜5％of primitive cells and the group with a ratio of ≥5％of primitive cells([12.75±2.82]months vs[10.45±1.74]months,P＜0.05).Cox regression analysis showed that white blood cell count and peripheral blood primordial cell ratio were influencing factors for the survival outcome of CMML patients(P＜0.05),while other indicators had no significant impact on the survival outcome of CMML patients(P＞0.05).Conclusion:The proportion of peripheral blood primordial cells is related to the risk stratifica-tion of prognosis in CMML patients,and the higher the proportion of peripheral blood primordial cells before treatment,the worse the survival outcome.
关键词
慢性粒单核细胞白血病/外周血原始细胞比例/预后危险度分层Key words
chronic myelomonocytic leukemia/the proportion of peripheral blood primitive cells/prognostic risk stratification引用本文复制引用
出版年
2024
NETL
NSTL
万方数据