Analysis of HIV detection status and tracking status of single-reagent reactive blood donors in Yinchuan area
Objective:To track and test HIV antigen/antibody(HIV-AG/Ab1+2)single-reagent reactive blood donors,and provide evidence for the feasibility of blood donor rejoining the team.Methods:From 2022 to 2023,85 blood donors who were screened due to the single reagent reactivity of HIV-AG/Ab1+2 test were col-lected,and re-sampled by telephone.The reagents of two manufacturers were used for HIV-AG/Ab1+2 detec-tion(ELISA),and the single test mode was used for nucleic acid detection(HIV NAT).The anti-HIV confirma-tion test and Western blot test(WB)were supplemented,and the blood donors who could return were determined by analyzing the test data according to the return procedure.Results:A total of 87 654 HIV-Ag/Ab1+2 samples were tested with reagents from the two manufacturers,and 85 were reactive with single reagent,which were all negative by Centers for Disease Control and Prevention(CDC).In the first round of return,85 blood donors were recalled by telephone and 46 were re-sampled(39 cases could not be recalled because they were not in the local area or could not be contacted).One case of ELISA double reagent,NAT and WB were positive,and the blood donors were permanently shielded,20 cases were still single reagent reactivity,and 25 cases could participate in blood do-nation after removal of shielding,with a return rate of 54.3％(25/46).In the second round,20 blood donors were recalled,16 of them were still single-reagent reactive,and 4 were able to participate in blood donation after being released from screening.The total return rate was 63.0％(29/46).The results of blood donation test of 29 re-turned blood donors were all qualified.Conclusion:It may be safe and feasible to use ELISA double reagent plus NAT single test and WB confirmation test for returning blood donors with single reagent reaction.It is necessary to use two manufacturers'reagents in blood donor ELISA screening test.The return test can eliminate the doubts of blood donors and make those who are willing to donate blood continue to participate in blood donation.
blood donor trackingblood donors return to the teamsingle reagent reactivitynucleic acid testing
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