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Rh系统简单特异性自身抗体血清学鉴定与分析

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目的:通过2例Rh系统简单特异性自身抗-e抗体案例的鉴定和分析,了解简单特异性自身抗体的血清学特征.方法:采用常规血清学方法对患者进行ABO、Rh表型分型,直接抗人球蛋白试验对患者血清及放散液中抗体进行检测;进一步采用不同表型细胞对患者血清吸收后进行抗体鉴定,并对吸收后细胞再次放散检测.结果:患者均为e抗原阳性,血清和放散液中表现出抗-e抗体格局,该抗体只能被e抗原阳性细胞吸收,而不能被e抗原阴性细胞吸收.结论:该2例抗体为简单特异性自身抗e抗体,不能被e抗原阴性细胞吸收,与类抗体特征存在区别.
Serological identification and analysis of simple Rh-specific autoantibodies
Objective:To understand the serological characteristic of simple specific autoantibodies by studies of 2 patients who produced simple specific auto anti-e antibodies.Methods:ABO,Rh phenotyping,DAT and anti-body identification were conducted by routine serological methods.Antibody identification was done using different phenotype RBCs with the eluting solution and absorbed serum.Results:Both 2 patients were e positive.The anti-bodies in serum and eluting solution were identified as anti-e which could not be absorbed by e negative RBCs.Conclusion:These two antibodies were simple specific auto anti-e.It cannot be absorbed by e negative RBCs which distinguish with mimicking antibody.

simple specific antibodyantibody identificationanti-e antibody

张刘仟、马玲、邵雷、臧炫月、尤建国

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淮安市第一人民医院输血科(江苏淮安,223300)

江苏省血液中心输血研究室

简单特异性自身抗体 抗体鉴定 抗-e

2024

临床血液学杂志
华中科技大学同济医学院血液病研究所 北京医科大学血液病研究所

临床血液学杂志

CSTPCD
影响因子:1.063
ISSN:1004-2806
年,卷(期):2024.37(8)