Application of antibody type and titer in blood products and donor retention
Objective:To investigate the blood washing scheme and clinical application of blood donors with ir-regular antibody and the shielding and returning model of blood donors.Methods:Antibody screening and antibod-y specificity identification were carried out on blood samples with negative RhD confirmation,ABO positive and negative stereotyping,O-cell agglutination and hospital feedback with irregular antibodies,for blood donors with specific antibodies detected,the corresponding red blood cell products were washed according to the antibody type and potency and sent to the clinic,and the corresponding plasma products were scrapped,at the same time,a da-tabase of irregular antibody positivity was established,and a shielding interval was set for blood donors with anti-bodies detected according to titer and antibody type.Results:Among the 190 780 blood donors,186 cases(0.097％)were positive for irregular antibodies,washed 3 times routinely according to non-specific antibodies and specific antibody with a titer≤ 16,specific antibody with titer 16 was washed 4 times,a total of 186 bags of washed red blood cells were prepared and tested again to meet the requirements and sent to the clinic.The total qualified rate was 99.5％,and the qualified rate of titer≤ 16 was 100％.The corresponding database of blood do-nors with irregular antibody was established,IgM antibodies were shown to be suitable for whole blood donation and it was recommended that antibody screening be performed again when donating blood;Suspension of blood do-nation for IgG antibodies for 12 months and re-screening for antibodies at the time of donation were recommended.Conclusion:Screening and returning mode should be established for irregular antibody positive blood donors,and washing scheme should be established according to antibody type titer to prevent waste of blood resources and re-tain blood donor population.
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