Research progress of multiple myeloma cell-derived extracellular vesicles in clinical diagnosis and treatment
Multiple myeloma cell-derived extracellular vesicles(MM-EVs)are involved in multiple myeloma related processes such as angiogenesis,osteolysis,immune suppression,and drug resistance through intercellular communication by transporting specific bioactive cargo,so they can be used as potential biomarkers to assist in di-agnosis and new therapeutic strategies for multiple myeloma.This review summarizes the mechanism of MM-EVs remodeling the bone marrow microenvironment to promote the progression of multiple myeloma and their relation-ship with drug resistance.Finally,we illustrate their research progress as a biomarker and the clinical prospect of promoting the treatment of multiple myeloma including MM-EVs based therapeutic targets for interference com-munication and engineering modification.The purification and characterization,functional analysis and safety of specific MM-EVs are important challenges for their clinical transformation.
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