Study on relationship between serum gastrin-17 and platinum resistance recurrence after platinum chemotherapy in ovarian cancer
Objective:To explore the relationship between serum gastrin-17(G-17)and platinum resistance re-currence in ovarian cancer after platinum based chemotherapy.Methods:A retrospective collection of data was conducted on 104 patients with recurrent ovarian cancer after platinum chemotherapy treated at Hospital from Jan-uary 2017 to June 2023.According to the type of recurrence,they were divided into platinum resistant recurrence group(20 cases)and platinum sensitive recurrence group(84 cases).The clinical data and serum G-17 level at ad-mission were compared between the two groups,and the relationship between serum G-17 and the recurrence of platinum-resistant ovarian cancer after platinum chemotherapy was analyzed.Results:There was no statistical sig-nificant difference in general information such as age and pathological grade between the two groups(P＞0.05).The proportion of International Federation of Gynecology and Obstetrics(FIGO)stage Ⅲ-Ⅳ patients,Fagotti score,and human epididymal protein 4(HE4)levels in the platinum resistant recurrence group were higher than those in the platinum sensitive recurrence group(P＜0.05).The serum G-17 levels in the platinum resistant re-currence group before and after chemotherapy were higher than those in the platinum sensitive recurrence group(P＜0.05).Multiple logistic regression analysis showed that Fagotti score,HE4,serum G-17 levels before and after chemotherapy were associated with platinum resistance recurrence in ovarian cancer after platinum based chemotherapy(P＜0.05).According to the Restricted Cubic Spline Model analysis,there was a non-linear dose-response relationship between pre chemotherapy serum G-17 levels and platinum resistance recurrence in ovarian cancer after platinum drug chemotherapy(P＜0.05).When pre chemotherapy serum G-17＞8.29 pmol/L,the risk of platinum resistance recurrence in patients increased with the increase of indicator levels.Pre chemotherapy serum G-17 levels were used as a predictive indicator,a receiver operating characteristic curve was plotted.The results showed that the area under the curve of pre chemotherapy serum G-17 in ovarian cancer patients predicting platinum resistance recurrence after platinum chemotherapy was 0.755(95％CI 0.640-0.870),with sensitivity and specificity of 70.0％and 75.0％,respectively.Conclusion:The recurrence of platinum resistance in ovarian cancer patients after platinum based chemotherapy may be related to abnormal expression of serum G-17 levels be-fore chemotherapy.Abnormal elevation of serum G-17 levels may indicate a high risk of platinum resistance recur-rence in patients,and have certain predictive value for platinum resistance recurrence.
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