Bioinformatics study of Lutheran blood type BCAM gene in KIRC
Objective:To study the expression of Lutheran blood group basal cell adhesion molecule(BCAM)gene in Kidney renal clear cell carcinoma(KIRC)based on bioinformatics KIRC expression and its clinical signifi-cance.Methods:The unified and standardized Pan-Cancer dataset TCGA Pan-cancer(PANCAN,n=10 535,G=60 499)and clinical follow-up data were downloaded from the UCSC Xena data portal(https://xenabrowser.net/).Sangerbox,GEPIA and UALCAN databases were used for comprehensive analysis to evaluate the expres-sion level of Lutheran BCAM gene in KIRC and its potential value in clinical prognosis.Results:Lutheran blood type BCAM gene expression was different in different tumors.BCAM was significantly up-regulated in 14 tumors(P＜0.05),and significantly down-regulated in 12 tumors(P＜0.05).The expression of BCAM mRNA in KIRC tissues was significantly lower than that in normal tissues(6.59±0.94 vs 8.48±1.69,P＜0.05).The low ex-pression of BCAM in KIRC was closely related to high tumor stage,grade lymph node metastasis and distant me-tastasis(P＜0.05).The BAP1 gene was widely mutated in KIRC with a mutation rate of 34.7％.The mutation frequency of BCAM in KIRC with low BAP1 expression was significantly higher than that in KIRC with high BAP1 expression.Survival analysis showed that the expression level of BCAM was positively correlated with the overall survival of KIRC(P＜0.05).Based on univariate Cox and multivariate Cox regression analysis,low expression of BCAM was a risk factor for the prognosis of KIRC.Conclusion:Lutheran BCAM gene was low expressed in most KIRC,which might be related to the occurrence,development and poor prognosis of KIRC.It might be used as an important indicator for the diagnosis and treatment of KIRC.
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