Effect and correlation of LDL/HDL and apoB/apoA1 on lupus nephritis with different degrees of renal injury
Objective:To analyze the effects and correlations of low-density lipoprotein to high-density lipopro-tein ratio(LDL/HDL)and apolipoprotein B to apolipoprotein A1 ratio(apoB/apoA1)on lupus nephritis(LN)with different degrees of renal injury.Methods:A retrospective analysis was conducted on 134 LN patients diagnosed and treated in our hospital.Patients were divided into renal insufficiency group and normal renal function group based on glomerular filtration rate(e-GFR).The effects of LDL/HDL,apoB/apoA1 on renal insufficiency LN were analyzed by univariate and multivariate methods.The relationship and correlation between LDL/HDL,apoB/apoA1,and different e-GFR levels were explored through multiple linear regression and correlation analysis.Results:Univariate and binary logistic regression analysis showed that disease course,LDL/HDL,apoB/apoA1,C3,anti-dsDNA positive,and SLEDAI were all influencing factors of LN,the OR values were 1.084,5.669,31.738,0.490,3.427 and 1.351,respectively(all P＜0.05).Before and after correcting for confounding factors,LDL/HDL and apoB/apoA1 were still risk factors for e-GFR＜90 mL/min/1.73 m2,e-GFR＜60 mL/min/1.73 m2 and e-GFR＜30 mL/min/1.73 m2.LDL/HDL,apoB/apoA1 were associated with a decrease in e-GFR at different stages,and the correlation from strong to weak were from stages 3,2,4-5 and 1.Pearson correlation analysis showed that LDL/HDL and apoB/apoA1 were negatively correlated with e-GFR in patients with different stages of kidney injury.The correlation continued to increase in stages 1,2,and 3 of kidney injury,and slightly weakened in stages 4-5,showing a V-shaped trend.LDL/HDL and apoB/apoA1e assessed the area under the curve(AUC)of LN patients with e-GFR＜90 mL/min/1.73 m2,e-GFR＜60 mL/min/1.73 m2,and e-GFR＜30 mL/min/1.73 m2 were 0.679,0.744,0.700,0.673,0.730 and 0.711,respectively,and the AUC were higher than LDL,HDL,apoB and apo A1(P＜0.05).Conclusion:LDL/HDL,apoB/apoA1 might be risk factors for LN renal injury,and the correlation between LDL/HDL,apoB/apoA1,and e-GFR reduction in renal injury varies at different stages of renal injury were different.
NETL
NSTL
万方数据
