Study on distribution of Rh phenotype among hospitalized patients in Handan area
Objective:To analyze the distribution characteristics of Rh phenotype among hospitalized patients in Handan area,and explore its value for clinical blood transfusion.Methods:The distribution of Rh phenotype in different ABO blood types.Rh antigen distribution,Rh phenotype distribution by gender,and whether Rh antigen phenotype and genotype comply with Hardy Weinberg's equilibrium law were analyzed respectively by investigating the Rh phenotype results of 13 892 patients in a hospital in Handan area from January 2021 to July 2023.Results:①The status of Rh phenotype:There was no statistically significant difference in the same Rh phenotype among different ABO blood types among 13 892 hospitalized patients(x2=39.75,P＞0.05).There was no statistically significant difference in Rh phenotype distribution frequency between patients of different genders(x2=6.549,P＞0.05).There was a statistically significant difference in the distribution of Rh phenotype between RhD posi-tive and negative inpatients(x2=4 526.157,P＜0.05).②Rh antigen distribution:The proportion of Rh antigens in RhD positive patients,from high to low,was e(91.99％),C(87.75％),c(59.54％)and E(50.15％).The proportion of RhD negative patients,from high to low,was e(41.94％),c(40.86％),C(11.83％)and E(5.38％).③Rh phenotype gene frequency:The frequencies of RhD positive combinations were CDe(0.622 4)＞cDE(0.282 7)＞cDe(0.020 1),respectively.The frequencies of RhD negative combination were cde(0.054 0)＞Cde(0.011 5)＞cdE(0.004 8)＞CdE(0.000 7),respectively.Gene frequency were C=0.638 4,c=0.361 6,D=0.923 8,d=0.076 2,E=0.292 0,e=0.708 0,and there was no statistically significant difference between the observed value and the expected value,which was consistent with the Hardy Weinberg distribution pattern of fit.Conclusion:Based on the distribution pattern of Rh phenotype in the local area,the Rh isotype or compatibili-ty protocol was preferred.When the blood stocks could not be satisfied,the corresponding blood component could be selected according to the probability of producing irregular antibodies.Matching Rh phenotype compatible blood for patients could provide a basis for precise blood transfusion in clinical practice scientifically and reasonably.
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