Emergency treatment strategy and transfusion effect evaluation of difficult blood matching caused by non-specific antibodies
Objective:To explore emergency blood transfusion strategies for patients with non-specific antibod-ies in the body and evaluate the effectiveness of blood transfusion treatment.Methods:44 patients with non-specif-ic antibodies causing difficulty in cross matching in our hospital from January 2021 to February 2024 were selected as the research subjects.They were classified according to disease and blood type,and transfusion compatibility tests were conducted using saline test tube method,microcolumn agglutination method,polyamine method,anti globulin method,etc.Targeted transfusion strategies were formulated,and the effect of transfusion treatment was evaluated by comparing the changes in Hb before and after transfusion.Results:The production of non-specif-ic antibodies was mainly seen in autoimmune diseases such as autoimmune hemolytic anemia and systemic lupus erythematosus.The Rh blood group distribution of non-specific antibody patients was DCCee,accounting for 50％,the highest proportion,followed by DCcEe,accounting for 18.18％.Selection of washed red blood cells with ABO and Rh blood types that matched or were less than the patient's antigen,and using the"lowest mis-match"principle for transfusion,31 patients(75.61％)showed significant transfusion effects,9 patients(21.95％)partially effective,and 1 patient(2.44％)had ineffective transfusion.Conclusion:ABO and Rh pheno-type matching transfusion can effectively reduce the occurrence of transfusion adverse events and improve the ef-fectiveness of transfusion treatment.
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