Phenotypic distribution and transfusion strategy of RhD-positive blood donors in Nantong
Objective:To analyze the profiles of RhC,c,E,and e antigens and phenotypes in RhD-positive blood donors from Nantong,so as to provide data for compatibility blood transfusion of Rh blood group.Methods:Blood donors in Nantong from September 5,2023 to November 7,2023 were randomly selected,and C,c,E,and e antigens were detected by microcolumn gel card method to determine the Rh phenotype.The Chi-sequare test and Fisher's exact test were used to analyze antigen frequency and Rh phenotypes in each region.Results:Among the 1 534 Rh-positive blood donors,the frequency of C,c,E,and e antigen was e(93.42％)＞C(89.50％)＞c(58.67％)＞E(50.59％),and Rh phenotypes distribution was Ce(40.35％)＞CcEe(38.98％)＞Cce(8.80％)＞cE(6.19％)＞cEe(4.04％)＞CEe(0.98％)＞CcE(0.39％)＞ce(0.26％)＞CE(0),the probability of compatibili-ty between different phenotypes was CcEe(100.00％)＞Cce(49.41％)＞CEe(41.33％)＞Ce(40.35％)＞cEe(10.23％)＞CcE(6.58％)＞cE(6.19％)＞ce(0.26％)＞CE(0).Difference of Rh phenotype distribution between male and female were not noticed in Nantong(P＞0.05).There was significant difference in Rh blood type distri-bution among Nantong,Nanning,Guangzhou,Shenzhen and Fuzhou(x2=315.626,P＜0.001).Conclusion:The phenotypic distribution characteristics of RhD-positive blood donors in Nantong have regional differences.The re-gional phenotypic distribution characteristics should be considered to select an appropriate compatible transfusion strategy,and precise transfusion should be implemented to ensure safety when implementing Rh compatible trans-fusion.
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